Welcome to the Fajgenbaum Lab, where we work to form a better understanding of Castleman Disease and other Cytokine Storm Disorders
Scientists at the CSTL conduct research across many subfields of science with the goal of improving the diagnosis, treatment, and management of Castleman Disease and other cytokine storm disorders. Our group is unique in that instead of focusing on one experimental technique, or subfield, our lab uses multiple techniques and technologies to study Castleman disease (and related diseases) from multiple angles. To fulfill this goal, the CSTL recruits scientists from different backgrounds and expertise such as basic bench research, biobanking, and data analysis.
Our interests include elucidating the etiology, dysregulated cell types, signaling pathways, and effector cytokines in idiopathic multicentric Castleman disease (iMCD) and related cytokine storm disorders; identifying effective treatments for iMCD patients; PI3K/Akt/mTOR signaling in iMCD; understanding the role of stromal cells and chemokines in iMCD.
Our research projects are divided into five major broad categories: Defining CD and its clinico-pathology; Etiology of CD; Pathophysiology; Treatment effectiveness studies; and rare-disease sample acquisition methodologies.
Learn More about our Center
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Meet the Team
Led by Dr. David Fajgenbaum, the CSTL comprises an interdisciplinary mix of clinical data analysts, cell biologists, lab technicians, physicians, and data scientists all with a unifying goal of learning everything we can about Castleman Disease and other hyperinflammatory disorders.
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Learn About our Work
Here at the CSTL we have utilize a number of technologies and techniques to answer questions about Castleman Disease and other cytokine storm disorders. This includes dissecting clinical data from patients, studying the genetic components of the disease, and using cell based technologies to better understand pathology. Learn more about our individual projects by visting our Projects page!
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Learn About Recent Events in the Lab!
With so many moving pieces, it’s often difficult to keep up with everything going on in our Center! Check out our blog series to get a rundown of recent events in the lab.
March Events
March 27 - CSTL website created